Danny Porath

Towards Molecular Conductors: Advances in Charge Transport Through Individual DNA and DNA-Based Molecules

PH 127

23.05.2018, 09:29

DNA is primarily and with no doubt the most important biological molecule. Its double-strand recognition, as well as the ability to control its sequence and manipulate its structure open a multitude of ways to make it useful for molecular electronics. Step by step we improve the synthesized constructs and the measurement methods of single DNA-based molecules. In this lecture I will review the field and report on our progress in producing and measuring DNA-based building blocks towards the construction of DNA-based programmable circuits.


[1] "Direct measurement of electrical transport through DNA molecules", Danny Porath, Alexey Bezryadin, Simon de Vries and Cees Dekker, Nature 403, 635 (2000).

[2] "Charge Transport in DNA-based Devices", Danny Porath, Rosa Di Felice and Gianaurelio Cuniberti, Topics in Current Chemistry Vol. 237, pp. 183-228 Ed. Gary Shuster. Springer Verlag, 2004.

[3] “Direct Measurement of Electrical Transport Through Single DNA Molecules of Complex Sequence”, Hezy Cohen, Claude Nogues, Ron Naaman and Danny Porath, PNAS 102, 11589 (2005).

[4] “Long Monomolecular G4-DNA Nanowires”, Alexander Kotlyar, Nataly Borovok, Tatiana Molotsky, Hezy Cohen, Errez Shapir and Danny Porath, Advanced Materials 17, 1901 (2005).

[5] “Electrical characterization of self-assembled single- and double-stranded DNA monolayers using conductive AFM”, Hezy Cohen et al., Faraday Discussions 131, 367 (2006).

[6] “High-Resolution STM Imaging of Novel Poly(G)-Poly(C)DNA Molecules”, Errez Shapir, Hezy Cohen, Natalia Borovok, Alexander B. Kotlyar and Danny Porath, J. Phys. Chem. B 110, 4430 (2006).

[7] "Polarizability of G4-DNA Observed by Electrostatic Force Microscopy Measurements", Hezy Cohen et al., Nano Letters 7(4), 981 (2007).

[8] “Electronic structure of single DNA molecules resolved by transverse scanning tunneling spectroscopy”, Errez Shapir et al., Nature Materials 7, 68 (2008).

[9] “A DNA sequence scanned”, Danny Porath, Nature Nanotechnology 4, 476 (2009).

[10] “The Electronic Structure of G4-DNA by Scanning Tunneling Spectroscopy”, Errez Shapir, et.al., J. Phys. Chem. C 114, 22079 (2010).

[11] “Energy gap reduction in DNA by complexation with metal ions”, Errez Shapir, G. Brancolini, Tatiana Molotsky, Alexander B. Kotlyar, Rosa Di Felice, and Danny Porath, Advanced Maerials 23, 4290 (2011).

[12] "Quasi 3D imaging of DNA-gold nanoparticle tetrahedral structures", Avigail Stern, Dvir Rotem, Inna Popov and Danny Porath, J. Phys. Cond. Mat. 24, 164203 (2012).

[13] "Comparative electrostatic force microscopy of tetra- and intra-molecular G4-DNA", Gideon I. Livshits, Jamal Ghabboun, Natalia Borovok, Alexander B. Kotlyar, Danny Porath, Advanced materials 26, 4981 (2014).

[14] "Long-range charge transport in single G4-DNA molecules", Gideon I. Livshits et. al., Nature Nanotechnology 9, 1040 (2014).

[15] "Synthesis and Properties of Novel Silver containing DNA molecules", Gennady Eidelshtein et. al., Advanced Materials 28, 4839 (2016).

[16] "Highly conductive thin uniform gold-coated DNA nanowires", Avigail Stern et. al., Advanced Materials In press/online (2018).