Naoko Mizuno

Cell shape formation controlled by cytoskeleton

PH 127

26.01.2018, 13:00


Controlling cell shape is an essential function of all cells, which allows adjusting and adapting to various environments and requirements. This is critical in a number of cellular processes, particularly during cell polarization and migration. Combinations of several signaling pathways often initiate changes of the cell shape and the outcome is seen as a remodeling of membrane- or cytoskeleton structures that provide a binding scaffold for various factors facilitating cellular responses. These factors include the receptors for extra-cellular stimuli, adhesion signaling factors, microtubule-associated proteins (MAPs) such as microtubule plus-end tracking proteins and microtubule severing proteins. Dynamic behavior of the membrane-actin interactions and microtubules are implicated in these actions, however, the mechanism of this remodeling of the cytoskeleton is widely unknown. Using combinations of the hybrid methods of cryo-EM and biophysics, our focus is to elucidate the mechanism of the cell shape formation and the downstream cytoskeleton remodeling.