Prof. Dr. Erich Sackmann

Physics of the cell. Exploration of the interactive control of material propertiesof cells by signal molecules and mutations. Main topics: Composite membrane microstructure and functions; mesoscale viscoelasticity and plasticity of cells; physics of cell shape changes; actin-microtubule cross talk. Control of cell adhesion by interplay of specific and generic interfacial forces membrane elasticity and actin-microtubule crosstalk. Transient generation of local and global reaction spaces in membranes by lateral phase separation and actin gel reorgansiation.

Latest Publications

A. Zidovska and E. Sackmann (2011)
On the mechanical stability of filopodia
Biophys. J. 100 1–10


E. Sackmann (2011)
Quantal law of immune response
New J Phys. in press


Zidovska Alexandra and Erich Sackmann, 2006. Phys. Brownian Motion of Nucleated Cell Envelopes Impedes Adhesion. Phys. Rev. Lett. 96, 048103 Arzinet, Bernd Meier, Erich Sackmann, Joachim O. Rädler, and Doris Heinrich. Temporal Analysis of Active and Passive Transport in Living Cells (2008) Phys. Rev. Lett. 101, 248103 Sackmann, Erich, Felix Keber and Doris Heinrich. 2010. Physics of Cellular Movements. Annu.Rev. Condens. Matter Phys. 1:257–76 Sackmann, Erich. 2011. Quantal law of immune response New J. Physics 13, 065013 Sackmann, Erich.2014. Endoplasmatic reticulum shaping by generic mechanisms and protein-induced spontaneous curvature Adv. Colloid .Interface Sci. 208, 153–160 Sackmann Erich, and Smith, Ana. 2014, Physics of cell adhesion: some lessons from cell biomimetic systems. Soft Matter, 10, 1644-1649 Sackmann Erich. 2015. How actin/myosin crosstalks guide the adhesion, locomotion and polarization of cells. Biochim. Biophys. Acta 1853, 3132–3142.

08.01.2018

Summary of Sackmanns Research Fields

Summary Research fields

1962-1965: NMR spectroscopy of 13C-H-spin-spin coupling mechanisms in organic molecules,

1967-1975 (a) Liquid Crystals: Scientific and practical applications (b) Photophysics of organic single crystal

1972-1995: Biological Physics: Bottom-up design of mimetics of biological composite membranes, Scientific aims: (i) Exploration of the thermomechanics of the self-assembly of functional domains in biological membranes, (ii) Design of biomimetic systems to study the physical basis of cell-cell- and cell-tissue-adhesion.

1992-2000: Physical basis of the biological function of (passive and active) actin-based intracellular macromolecular scaffolds based on comparative studies of the microscopic viscoelastic impedances of in vitro models of and living cells.

1995-2017: Physics of the Cell. (i) Physical basis of cell adhesion and polarized cell migration in tissue (ii) Logistically controlled self-assembly of intracellular functional machines-(iii) Analogies between technical and biological control systems.

Since 2000:Bionics: Biological evolution as interplay of physics and genetics- Learning from nature to overcome evolutionary crises