Bausch Group

Understanding complex biomaterials on a fundamental physical basis is an integral challenge of future biophysical research. This challenge can be addressed by the concerted application of new experimental tools of soft condensed matter physics to living cells and bio-mimetic model systems.

In our group we concentrate on the one hand on developing new physical tools to address the underlying complexity and mechanisms and on the other hand on developing new biomaterials for applications ranging from biomedicine to functional food.

 

Topology and Dynamics of Active Nematic Vesicles

We have implemented a minimalistic model of of a shape-changing cell that moves on its own. Basically our synthetic biology approach combines only a few molecular ingredients: microtubule polymers and kinesin motors are encapsulated into a vesicle by a lipid bilayer. We observe a rich variety of morphologies that can be explained by geometrical and topological effects on the nematic microtubule cortex.

READ MORE ON VESICLE IN MOTION

Variety of Vesicle Shapes. Artwork, (c) C. Hohmann, Nano Initiative Munich

Latest Publications

 

F. C. Keber, E. Loiseau, T. Sanchez, S. J. DeCamp, L. Giomi, M. J. Bowick, M. C. Marchetti, Z. Dogic and A. R. Bausch (2014)
Topology and Dynamics of Active Nematic Vesicles
Science, 345, 6201. Link:  [download]


N. Elkhatib, M. B. Neu, C. Zensen, K. M. Schmoller, D. Louvard, A. R. Bausch, T. Betz, D. M. Vignjevic (2014)
Fascin Plays a Role in Stress Fiber Organization and Focal Adhesion Disassembly
Current Biology, 24, 1492-1499 Link:  [download]



Research Areas

Complex Microfluidics and Biomaterials
Cytoskeleton and Biopolymer Networks
Pattern Formation
Nanoscopy
Completed Projects