Bausch Group

Understanding complex biomaterials on a fundamental physical basis is an integral challenge of future biophysical research. This challenge can be addressed by the concerted application of new experimental tools of soft condensed matter physics to living cells and bio-mimetic model systems.

In our group we concentrate on the one hand on developing new physical tools to address the underlying complexity and mechanisms and on the other hand on developing new biomaterials for applications ranging from biomedicine to functional food.


Artwork, (c) Fabian Hecht, C. Hohmann, Nano Initiative Munich

Kinetically guided colloidal structure formation

Colloidal structure formation far from equilibrium is a well-known process to self-assemble large fractal gels. We show that in this regime of quick struture formation, a multi-component system of DNA coated colloids can be kinetically tuned to create also finite sized but complex structures by rational design.

READ MORE ON COLLOIDAL STRUCTURE FORMATION

Artwork, (c) C. Hohmann, Nano Initiative Munich

Topology and Dynamics of Actice Nematic Vesicles

We have implemented a minimalistic model of of a shape-changing cell that moves on its own. Basically our synthetic biology approach combines only a few molecular ingredients: microtubule polymers and kinesin motors are encapsulated into a vesicle by a lipid bilayer. We observe a rich variety of morphologies that can be explained by geometrical and topological effects on the nematic microtubule cortex.

READ MORE ON VESICLE IN MOTION

Latest Publications

 

F. M. Hecht and A. R. Bausch (2016)
Kinetically guided colloidal structure formation
PNAS Early Edition, doi: 10.1073/pnas.1605114113 Link:  [download]


J. Deek, F. Hecht, L. Rossetti, K. Wißmiller, A. R. Bausch (2016)
Mechanics of soft epithelial keratin networks depend on modular filament assembly kinetics
Acta Biomaterialia, in press, doi:10.1016/j.actbio.2016.07.010 Link:  [download]



Research Areas

Complex Microfluidics and Biomaterials
Cytoskeleton and Biopolymer Networks
Pattern Formation
Nanoscopy
Completed Projects