Rief Group

Prof. Dr. Matthias Rief

Proteins are fascinating examples of self-organized molecular machines. Without any help a polypeptide strand can fold into functional threedimensional structures. We are interested in studying the function and folding process of proteins on the single molecule level. Examples are single molecule folding/unfolding studies or the motility of molecular motors in optical traps.

Latest Publications


Bauer D., Meinhold S., Jakob R.P., Stigler J., Merkel U., Maier T., Rief M., Žoldák G. (2018)
A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy
PNAS, vol 115, no. 18 Link:  (download)

Suren Th., Rutz D., Moessmer P., Merkel U., Buchner J. and Rief M. (2018)
Single-molecule force spectroscopy reveals folding steps associated with hormone binding and activation of the glucocorticoid receptor
PNAS vol. 115, Nr. 46, 11688-11693 Link:  [download]

Research Areas

Protein Folding
Molecular Machines
Cytoskeletal Mechanics
Optical Trap Setup