Rief Group

Prof. Dr. Matthias Rief

Proteins are fascinating examples of self-organized molecular machines. Without any help a polypeptide strand can fold into functional threedimensional structures. We are interested in studying the function and folding process of proteins on the single molecule level. Examples are single molecule folding/unfolding studies or the motility of molecular motors in optical traps.

Latest Publications


L. Rognoni, T. Möst, G. Zoldak. M. Rief (2014)
Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin
PNAS Link:  [download]

J. Fang, A. Mehlich, N. Koga, J. Huang, R. Koga, X. Gao, Ch. Hu, Ch. Jin, M. Rief, J. Kast, D. Baker, H. Li (2013)
Forced protein unfolding leads to highly elastic and tough protein hydrogels
Nature Communications 4, 2974, 10.1038 Link:  [download]

Research Areas

Protein Folding
Protein-Protein Interactions
Molecular Motors
Cytoskeletal Mechanics