Rief Group

Prof. Dr. Matthias Rief

Proteins are fascinating examples of self-organized molecular machines. Without any help a polypeptide strand can fold into functional threedimensional structures. We are interested in studying the function and folding process of proteins on the single molecule level. Examples are single molecule folding/unfolding studies or the motility of molecular motors in optical traps.

Latest Publications


K. Austen, P. Ringer, A. Mehlich, A. Chrostek-Grashoff, C. Kluger, Chr. Klingner, B. Sabass, R. Zent, M. Rief and C. Grashoff (2015)
Extracellular rigidity sensing by talin isoform-specific mechanical linkages

D. Bauer, D.R. Merz, B. Pelz, K.E. Theisen, G.Yacshyn, D. Mokranjac, R.I. Dima, M. Rief, and G. Zoldák (2015)
Nucleotides regulate the mechanical hierarchy between subdomains of the nucleotide binding domain of the Hsp70 chaperone DnaK
PNAS 2015 112 (33) 10389-10394 Link: www.pnas.org/content/112/33/10389.abstract

Research Areas

Protein Folding
Protein-Protein Interactions
Molecular Motors
Cytoskeletal Mechanics