Rief Group

Prof. Dr. Matthias Rief

Proteins are fascinating examples of self-organized molecular machines. Without any help a polypeptide strand can fold into functional threedimensional structures. We are interested in studying the function and folding process of proteins on the single molecule level. Examples are single molecule folding/unfolding studies or the motility of molecular motors in optical traps.

Latest Publications


Z Ganim, M Rief (2017)
Mechanically switching single-molecule fluorescence of GFP by unfolding and refolding
PNAS, vol 114, no. 42, pp 11052-11056 Link: [download]

P Ringer, A Weißl, A L Cost, A Freikamp, B Sabass, A Mehlich, M Tramier, M Rief, C Grashoff (2017)
Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1
Nature Methods volume 14, pp 1090-1096 Link: [download]

Research Areas

Protein Folding
Molecular Machines
Cytoskeletal Mechanics
Optical Trap Setup