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Publications of the Rief Group

Bauer D., Meinhold S., Jakob R.P., Stigler J., Merkel U., Maier T., Rief M., Žoldák G. (2018)
A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy
PNAS, vol 115, no. 18 Link:  (download)

Suren Th., Rutz D., Moessmer P., Merkel U., Buchner J. and Rief M. (2018)
Single-molecule force spectroscopy reveals folding steps associated with hormone binding and activation of the glucocorticoid receptor
PNAS vol. 115, Nr. 46, 11688-11693 Link:  [download]

KM Tych, M. Jahn, H. Girstmair, T. Hugel, J. Buchner, M. Rief (2018)
Unravelling the Mechanics of a Molecular Chaperone
Biophysical Journal 114 (3), 552a Link:  [download]

M Jahn, K Tych, H Girstmair, M Steinmaßl, T Hugel, M Rief (2018)
Folding and Domain Interactions of Three Orthologs of Hsp90 Studied by Single-Molecule Force Spectroscopy
Structure 26 (1), 96-105 Link:  [download]

Z Ganim, M Rief (2017)
Mechanically switching single-molecule fluorescence of GFP by unfolding and refolding
PNAS, vol 114, no. 42, pp 11052-11056 Link: [download]

P Ringer, A Weißl, A L Cost, A Freikamp, B Sabass, A Mehlich, M Tramier, M Rief, C Grashoff (2017)
Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1
Nature Methods volume 14, pp 1090-1096 Link: [download]

S. S. Mandal, D. R. Merz, M. Buchsteiner, R. I. Dima, M. Rief and G. Zoldak (2017)
Nanomechanics of the substrate binding domain of Hsp70 determine its allosteric ATP-induced conformational change
PNAS, June, 114 (23), p.p. 6040-6045 Link:  [download]

M. Grison, U. Merkel, J. Kostian, Kr. Djinovic-Carugo, M. Rief (2017)
alpha-Actinin/titin interaction: A dynamic and mechanically stable cluster of bonds in the muscle Z-disk

F. Kilchherr, Chr. Wachauf, B. Pelz, M. Rief, M. Zacharias, H. Dietz (2016)
Single-molecule dissection of stacking forces in DNA
Science, Vol. 353, Issue 6304 Link:

M. Jahn, J. Buchner, T. Hugel and M. Rief (2016)
Folding and assembly of the large molecular machine Hsp90 studied in single-molecule experiments

K. Austen, P. Ringer, A. Mehlich, A. Chrostek-Grashoff, C. Kluger, Chr. Klingner, B. Sabass, R. Zent, M. Rief and C. Grashoff (2015)
Extracellular rigidity sensing by talin isoform-specific mechanical linkages

D. Bauer, D.R. Merz, B. Pelz, K.E. Theisen, G.Yacshyn, D. Mokranjac, R.I. Dima, M. Rief, and G. Zoldák (2015)
Nucleotides regulate the mechanical hierarchy between subdomains of the nucleotide binding domain of the Hsp70 chaperone DnaK
PNAS 2015 112 (33) 10389-10394 Link:

J. Stigler and M. Rief (2015)
Ligand-Induced Changes of the Apparent Transition-State Position in Mechanical Protein Unfolding
Bio. Phys. Journal, 109, 365-372 Link:

H.G. Hocking, F. Häse, T. Madl, M. Zacharias, M. Rief, and G. Zoldák (2015)
A Compact Native 24-Residue Supersecondary Structure Derived from the Villin Headpiece Subdomain
Bio.Phys. Journal, 108, 678-686 Link:

M. Jahn, A. Rehn, B. Pelz, B. Hellenkamp, K. Richter, M. Rief, J. Buchner and T. Hugel (2014)
The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function
PNAS 2014 111 (50) 17881-17886 Link:

L. Rognoni, T. Möst, G. Zoldak. M. Rief (2014)
Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin
PNAS Link:  [download]

J. Fang, A. Mehlich, N. Koga, J. Huang, R. Koga, X. Gao, Ch. Hu, Ch. Jin, M. Rief, J. Kast, D. Baker, H. Li (2013)
Forced protein unfolding leads to highly elastic and tough protein hydrogels
Nature Communications 4, 2974, 10.1038 Link:  [download]

G. Žoldák, J. Stigler, B. Pelz, H. Li and M. Rief (2013)
Ultrafast folding kinetics and cooperativity of villin headpiece in single-molecule force spectroscopy
PNAS November 2013 110(45), pp 18156-18161 Link: [download]

E. Pfitzner, C. Wachauf, F. Kilchherr, B. Pelz, W. Shih, M. Rief and H. Dietz (2013)
Rigid DNA beams for high-resolution single-molecule mechanics
Angewandte Chemie International Edition, Vol 52 (2013), 7766 [Download]

M. Hinczewski, JC Gebhardt, M. Rief, D. Thirumalai (2013)
From mechanical folding trajectories to intrinsic energy landscapes of biopolymers

M. Bertz, J. Buchner, M. Rief (2013)
Mechanical Stability of the Antibody Domain CH 3 Homodimer in Different Oxidation States
J Am Chem Soc Link:  [download]

Zoldak. G., and Rief, M. (2013)
Force as a single molecule probe of multidimensional protein energy landscapes
Curr Opin Struct Biol. Link:  [download]

L. Rognoni, J. Stigler, B. Pelz, J. Ylänne, M. Rief (2012)
Dynamic force sensing of filamin revealed in single-molecule experiments
PNAS, 109, 19679-19684 Link:  [download]

von Hansen, Y., Mehlich, A., Pelz, B., Rief M., and Netz, R.R. (2012)
Auto- and cross-power spectral analysis of dual trap optical tweezer experiments using Bayesian inference
Rev Sci Instrum 83, 095116 Link:  [download]

Stigler, J., and Rief, M. (2012)
Calcium-dependent folding of single calmodulin molecules
Proc Natl Acad Sci U S A Link:  [download]

M. Brunnbauer, R. Dombi, T. H. Ho, M. Schliwa, M. Rief, Z. Ökten (2012)
Torque generation of Kinesin motors is governed by the stability of the neck domain
Molecular Cell 2, 147-58 Link:  [download]

N. Pinotsis, S. D. Chatziefthimiou, F. Berkemeier, F. Beuron, I. M. Mavridis, P. V. Konarev, D. I. Svergun, E. Morris, M. Rief, M. Wilmanns (2012)
Superhelical architecture of the Myosin filament-linking protein myomesin with unusual elastic properties
PLos Biol, 10(2): e1001261 Link:  [download]

J. Stigler, M. Rief (2012)
Hidden Markov Analysis of Trajectories in Single-Molecule Experiments and the Effects of Missed Events
ChemPhysChem, 13, 1079–1086 Link:  [download]

J. Stigler, F. Ziegler, A. Gieseke, J. C. M. Gebhardt and M. Rief (2011)
The complex folding network of single calmodulin molecules
Science, 334, 512-516 Link:  [download]

F. Berkemeier, M. Bertz, S. Xiao, N. Pinotsis, M. Wilmanns, F. Grater, M. Rief (2011)
Fast-folding {alpha}-helices as reversible strain absorbers in the muscle protein myomesin
PNAS 34:14139-44 Link:  [download]

Schlierf, M., Yew, Z.T., Rief, M., et al. (2010)
Complex Unfolding Kinetics of Single-Domain Proteins in the Presence of Force
Biophysical Journal 99:1620-1627 Link:  [download]

Bertz,M., Chen,J., Feige,M.J., et al. (2010)
Structural and Mechanical Hierarchies in the alpha-Crystallin Domain Dimer of the Hyperthermophilic Small Heat Shock Protein Hsp16.5
Journal of Molecular Biology 400:1046-1056 Link:  [download]

J. C. M. Gebhardt, Z. Ökten, M. Rief (2010)
The Lever Arm Effects a Mechanical Asymmetry of the Myosin-V-Actin Bond
Biophysical Journal 98:277-281 Link:  [download]

Gebhardt, J. C., T. Bornschlogl, and M. Rief (2010)
Full distance-resolved folding energy landscape of one single protein molecule
Proc Natl Acad Sci U S A 107:2013-2018 Link:  [download]

M. Brunnbauer, F. Mueller-Planitz, S. Kösem, T. H. Ho, R. Dombi, J. C. M. Gebhardt, M. Rief, Z. Ökten (2010)
Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner
Proc Natl Acad Sci U S A 107:10460-10465 Link:  [download]

Pernigo, S., A. Fukuzawa, M. Bertz, M. Holt, M. Rief, R. A. Steiner, and M. Gautel (2010)
Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex
Proc Natl Acad Sci U S A 107:2908-2913 Link:  [download]

Yew, Z. T., M. Schlierf, M. Rief, and E. Paci (2010)
Direct evidence of the multidimensionality of the free-energy landscapes of proteins revealed by mechanical probes
Phys Rev E Stat Nonlin Soft Matter Phys 81:031923

Junker, J. P., and M. Rief (2010)
Evidence for a Broad Transition-States Ensemble in Calmodulin Folding from Single-Molecule Force Spectroscopy
Angew Chem Int Ed Engl 49: 3306 - 3309 Link:  [download]

Schlierf, M., and M. Rief (2009)
Surprising simplicity in the single-molecule folding mechanics of proteins
Angew Chem Int Ed Engl 48:820-822

Junker, J. P., F. Ziegler, and M. Rief (2009)
Ligand-dependent equilibrium fluctuations of single calmodulin molecules
Science 323:633-637

Junker, J. P., and M. Rief (2009)
Single-molecule force spectroscopy distinguishes target binding modes of calmodulin
Proc Natl Acad Sci U S A 106:14361-14366

Gebhardt, J., and M. Rief (2009)
Biochemistry. Force signaling in biology
Science 324:1278-1280

Bornschlogl, T., G. Woehlke, and M. Rief (2009)
Single molecule mechanics of the kinesin neck
Proc Natl Acad Sci U S A 106:6992-6997

Bornschlogl, T., J. C. Gebhardt, and M. Rief (2009)
Designing the Folding Mechanics of Coiled Coils

Bornschlogl, T., D. M. Anstrom, E. Mey, J. Dzubiella, M. Rief, and K. T. Forest (2009)
Tightening the knot in phytochrome by single-molecule atomic force microscopy
Biophys J 96:1508-1514

Bertz, M., M. Wilmanns, and M. Rief (2009)
The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk
Proc Natl Acad Sci U S A 106:13307-133310

Bertz, M., and M. Rief (2009)
Ligand binding mechanics of maltose binding protein
J Mol Biol 393:1097-1105

Bertz, M., and M. Rief (2009)
Ligand binding mechanics of maltose binding protein
J Mol Biol 393:1097-1105

Adio, S., J. Jaud, B. Ebbing, M. Rief, and G. Woehlke (2009)
Dissection of Kinesin's Processivity
PLoS ONE 4:e4612

Bornschlogl, T., and M. Rief (2008)
Single-molecule dynamics of mechanical coiled-coil unzipping
Langmuir 24:1338-1342

H. Dietz and M. Rief (2008)
Elastic bond network model for protein unfolding mechanics
Phys Rev Lett, vol 100, 098101 [Download]

Bertz, M., and M. Rief (2008)
Mechanical Unfoldons as Building Blocks of Maltose-binding Protein
J Mol Biol 378:447-458 Link: [download]

Bertz, M., A. Kunfermann, and M. Rief (2008)
Navigating the folding energy landscape of green fluorescent protein
Angew Chem Int Ed Engl 47:8192-8195

Schlierf, M., F. Berkemeier, and M. Rief (2007)
Direct Observation of Active Protein Folding Using Lock-in Force Spectroscopy
Biophys J 93:3989-3998

Khaire, N., R. Muller, R. Blau-Wasser, L. Eichinger, M. Schleicher, M. Rief, T. A. Holak, and A. A. Noegel (2007)
Filamin-regulated F-actin assembly is essential for morphogenesis and controls phototaxis in Dictyostelium
J Biol Chem 282:1948-1955 [Download]

Cappello, G., P. Pierobon, C. Symonds, L. Busoni, J. C. Gebhardt, M. Rief, and J. Prost (2007)
Myosin V stepping mechanism
Proc Natl Acad Sci U S A 104:15328-15333 Link: [download]

M. Mickler, R. Dima, H. Dietz, C. Hyeon, D. Thirumalai, and M. Rief (2007)
Revealing the bifurcation in the unfolding pathway of GFP by using single-molecule experiments and simulations
P Natl Acad Sci USA, vol 104, p20268 [Download]

H. Dietz, T. Bornschlögl, R. Heym, F. König, and M. Rief (2007)
Programming protein self-assembly with coiled coils
New J Phys, vol 9, p424 [Download]

H. Dietz and M. Rief (2007)
Detecting molecular fingerprints in single molecule force spectroscopy using pattern recognition
Jap J Appl Phys, vol 46-8B, p5540 [Download]

Schlierf, M., and M. Rief (2006)
Single-molecule unfolding force distributions reveal a funnel-shaped energy landscape
Biophys J 90:L33-35

Rief, M., J. P. Junker, M. Schlierf, K. Hell, and W. Neupert (2006)
Response to the Comment by Ainavarapu et al.
Biophys J 91:2011-2012

Jaud, J., F. Bathe, M. Schliwa, M. Rief, and G. Woehlke (2006)
Flexibility of the neck domain enhances Kinesin-1 motility under load
Biophys J 91:1407-1412

Gebhardt, J. C., A. E. Clemen, J. Jaud, and M. Rief (2006)
Myosin-V is a mechanical ratchet
Proc Natl Acad Sci U S A 103:8680-8685

Dietz, H., and M. Rief (2006)
Protein structure by mechanical triangulation
Proc Natl Acad Sci U S A 103:1244-1247

Dietz, H., M. Bertz, M. Schlierf, F. Berkemeier, T. Bornschlogl, J. P. Junker, and M. Rief (2006)
Cysteine engineering of polyproteins for single-molecule force spectroscopy
Nat Protoc 1:80-84

H. Dietz, F. Berkemeier, M. Bertz, and M. Rief (2006)
Anisotropic deformation response of single protein molecules
P Natl Acad Sci USA, vol 103, p12724 [Download]

H. Dietz and M. Rief (2006)
Protein structure by mechanical triangulation
P Natl Acad Sci USA, vol 103, p1244 [Download]

H. Dietz, M. Bertz, M. Schlierf, F. Berkemeier, T. Bornschlögl, J. Junker, and M. Rief (2006)
Cysteine engineering of polyproteins for single molecule force spectroscopy
Nature Protocols, vol 1, p80 [Download]

Dietz, H., F. Berkemeier, M. Bertz, and M. Rief (2006)
Anisotropic deformation response of single protein molecules
Proc Natl Acad Sci U S A 103:12724-12728

Bornschlogl, T., and M. Rief (2006)
Single molecule unzipping of coiled coils: sequence resolved stability profiles
Phys Rev Lett 96:118102

Berkemeier, F., M. Schlierf, and M. Rief (2006)
Mechanically controlled preparation of protein intermediates in single molecule experiments

Schwaiger, I., M. Schleicher, A. A. Noegel, and M. Rief (2005)
The folding pathway of a fast-folding immunoglobulin domain revealed by single-molecule mechanical experiments
Embo Reports 6:46-51

Schlierf, M., and M. Rief (2005)
Temperature Softening of a Protein in Single-molecule Experiments
J Mol Biol 354:497-503

Kufer, S. K., H. Dietz, C. Albrecht, K. Blank, A. Kardinal, M. Rief, and H. E. Gaub (2005)
Covalent immobilization of recombinant fusion proteins with hAGT for single molecule force spectroscopy
European Biophysics Journal with Biophysics Letters 35:72-78

Junker, J. P., K. Hell, M. Schlierf, W. Neupert, and M. Rief (2005)
Influence of substrate binding on the mechanical stability of mouse dihydrofolate reductase
Biophysical Journal 89:L46-L48

Hugel, T., M. Rief, M. Seitz, H. E. Gaub, and R. R. Netz (2005)
Highly stretched single polymers: Atomic-force-microscope experiments versus ab-initio theory
Physical Review Letters 94

Clemen, A. E. M., M. Vilfan, J. Jaud, J. S. Zhang, M. Barmann, and M. Rief (2005)
Force-dependent stepping kinetics of myosin-V
Biophysical Journal 88:4402-4410

S. Kufer, H. Dietz, C. Albrecht, K. Blank, A. Kardinal, M. Rief, and H. Gaub (2005)
Covalent immobilization of recombinant fusion proteins with hAGT for single molecule force spectroscopy
Eur Biophys J, vol 35, p72 [Download]

Schwaiger, I., A. Kardinal, M. Schleicher, A. A. Noegel, and M. Rief (2004)
A mechanical unfolding intermediate in an actin-crosslinking protein
Nature Structural & Molecular Biology 11:81-85

Dietz, H., and M. Rief (2004)
Exploring the energy landscape of GFP by single-molecule mechanical experiments
Proc Natl Acad Sci U S A 101:16192-16197

H. Dietz and M. Rief (2004)
Exploring the energy landscape of Green Fluorescent Protein by single-molecule mechanical experiments
P Natl Acad Sci USA, vol 101, p16192 [Download]

Zhuang, X. W., and M. Rief (2003)
Single-molecule folding
Current Opinion in Structural Biology 13:88-97

Krautbauer, R., M. Rief, and H. E. Gaub (2003)
Unzipping DNA oligomers
Nano Letters 3:493-496

Schwaiger, I., C. Sattler, D. R. Hostetter, and M. Rief (2002)
The myosin coiled-coil is a truly elastic protein structure
Nature Materials 1:232-235

Rief, M., and H. Grubmuller (2002)
Force spectroscopy of single biomolecules
Chemphyschem 3:255-261

Rock, R. S., M. Rief, A. D. Mehta, and J. A. Spudich (2000)
In vitro assays of processive myosin motors
Methods-a Companion to Methods in Enzymology 22:373-381

48. Rief, M., R. S. Rock, A. D. Mehta, M. S. Mooseker, R. E. Cheney, and J. A. Spudich (2000)
Myosin-V stepping kinetics: A molecular model for processivity
Proc Natl Acad Sci U S A 97:9482-9486

Rief, M., M. Gautel, and H. E. Gaub (2000)
Unfolding forces of titin and fibronectin domains directly measured by AFM
In Elastic Filaments of the Cell. 129-141

Clausen-Schaumann, H., M. Rief, C. Tolksdorf, and H. E. Gaub (2000)
Mechanical stability of single DNA molecules
Biophysical Journal 78:1997-2007

Clausen-Schaumann, H., M. Rief, and M. Seitz (2000)
Artificial noses sniff DNA
Chemphyschem 1:89-+

Viani, M. B., T. E. Schaffer, G. T. Paloczi, L. I. Pietrasanta, B. L. Smith, J. B. Thompson, M. Richter, M. Rief, H. E. Gaub, K. W. Plaxco, A. N. Cleland, H. G. Hansma, and P. K. Hansma (1999)
Fast imaging and fast force spectroscopy of single biopolymers with a new atomic force microscope designed for small cantilevers
Review of Scientific Instruments 70:4300-4303

Viani, M. B., T. E. Schaffer, A. Chand, M. Rief, H. E. Gaub, and P. K. Hansma (1999)
Small cantilevers for force spectroscopy of single molecules
Journal of Applied Physics 86:2258-2262

Rief, M., J. Pascual, M. Saraste, and H. E. Gaub (1999)
Single molecule force spectroscopy of spectrin repeats: Low unfolding forces in helix bundles
Journal of Molecular Biology 286:553-561

Rief, M., H. Clausen-Schaumann, and H. E. Gaub (1999)
Sequence-dependent mechanics of single DNA molecules
Nature Structural Biology 6:346-349

Oesterhelt, F., M. Rief, and H. E. Gaub (1999)
Single molecule force spectroscopy by AFM indicates helical structure of poly(ethylene-glycol) in water
New Journal of Physics 1

Mehta, A. D., R. S. Rock, M. Rief, J. A. Spudich, M. S. Mooseker, and R. E. Cheney (1999)
Myosin-V is a processive actin-based motor
Nature 400:590-593

Mehta, A. D., M. Rief, J. A. Spudich, D. A. Smith, and R. M. Simmons (1999)
Single-molecule biomechanics with optical methods
Science 283:1689-1695

Mehta, A. D., M. Rief, and J. A. Spudich (1999)
Biomechanics, one molecule at a time
Journal of Biological Chemistry 274:14517-14520

Ludwig, M., M. Rief, L. Schmidt, H. Li, F. Oesterhelt, M. Gautel, and H. E. Gaub (1999)
AFM, a tool for single-molecule experiments
Applied Physics a-Materials Science & Processing 68:173-176

Li, H. B., M. Rief, F. Oesterhelt, H. E. Gaub, X. Zhang, and J. C. Shen (1999)
Single-molecule force spectroscopy on polysaccharides by AFM - nanomechanical fingerprint of alpha-(1,4)-linked polysaccharides
Chemical Physics Letters 305:197-201

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