Publications of the Hugel Group

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M. Jahn, A. Rehn, B. Pelz, B. Hellenkamp, K. Richter, M. Rief, J. Buchner and T. Hugel (2014)
The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function
PNAS 2014 111 (50) 17881-17886 Link: www.pnas.org/content/111/50/17881.abstract


S. Schwenkert, T. Hugel & M. B. Cox (2014)
The Hsp90 ensemble: coordinated Hsp90–cochaperone complexes regulate diverse cellular processes
NSMB, 21, 12, 1021 (2014)


S. Kienle, M. Gallei, H. Yu, B. Zhang, S. Krysiak, B. N. Balzer, M. Rehahn, A. D. Schlüter, and T. Hugel (2014)
Effect of Molecular Architecture on Single Polymer Adhesion
Langmuir, 30 (15), 4351–4357 (2014)


C. Lumme et al. (2014)
Nucleotides and Substrates Trigger the Dynamics of the Toc34 GTPase Homodimer Involved in Chloroplast Preprotein Translocation
Structure, 22, 1–13 ( 2014)


J. Elbert , F. Krohm , C. Rüttiger , S. Kienle , H. Didzoleit ,B. N. Balzer , T. Hugel , B. Stühn , M. Gallei, and A. Brunsen (2014)
Polymer-Modified Mesoporous Silica Thin Films for Redox-Mediated Selective Membrane Gating
Adv. Funct. Mater., 24, 1591 (2014)


S. Krysiak, S. Liese, R. R. Netz and T. Hugel (2014)
Peptide Desorption Kinetics from Single Molecule Force Spectroscopy Studies
JACS, 136, 688 (2014)


C. Ratzke, B. Hellenkamp, T. Hugel (2014)
Four-colour FRET reveals directionality in the Hsp90 multicomponent machinery
Nature Communications 5:4192 | DOI: 10.1038/ncomms5192


B. N. Balzer, M. Gallei, K. Sondergeld, M. Schindler, P. Müller-Buschbaum, M. Rehahn, T. Hugel (2013)
Cohesion Mechanisms of Polystyrene-Based Thin Polymer Films
Macromolecules, 46 (18), 7406 (2013)


B.N. Balzer, S. Micciulla, S. Dodoo, M. Zerball, M. Gallei, M Rehahn, R. v. Klitzing and T. Hugel (2013)
Adhesion Property Profiles of Supported Thin Polymer Films
ACS Applied Materials & Interfaces [Download]


B. N. Balzer, M. Gallei, M. Hauf, M. Stallhofer, L. Wiegleb, A. Holleitner, M. Rehahn, T. Hugel (2013)
Nanoscale Friction Mechanisms at Solid–Liquid Interfaces
Angew. Chem. Int. Ed. 52,25, 6541 (2013) Link: onlinelibrary.wiley.com/doi/10.1002/anie.201301255/abstract


M. Khaneft, B. Stühn, J. Engstler, H. Tempel, J. Schneider, T. Pirzer, T. Hugel (2013)
Imbibition of polystyrene melts in aligned carbon nanotube arrays
J. Appl. Phys., 113, 074305 (2013)


S. Kienle, T. Pirzer, S. Krysiak, M. Geisler, T. Hugel (2013)
Measuring the interaction between ions, biopolymers and interfaces – one polymer at a time
Faraday Disc, 160, 329 (2013)


Frank Stetter, Thorsten Hugel (2013)
The nanomechanical properties of Lipid Membranes are significantly influenced by the presence of Ethanol
Biophys. J., 104, 1049 (2013)


S. Dodoo, B. N. Balzer, T. Hugel, A. Laschewsky, R.v. Klitzing (2013)
Effect of ionic strength and layer number on swelling of polyelectrolyte multilayers in water vapour
Soft Materials, 11:2, 157-164


N. Schwierz, D. Horinek, S. Liese, T. Pirzer, B. Balzer, T. Hugel, R. Netz (2012)
On the relationship between peptide adsorption resistance and surface contact angle: A combined experimental and simulation single-molecule study
JACS, 134, 19628 (2012)


C. Ratzke, M. N. T. Nguyen, M. P. Mayer, T. Hugel (2012)
From a Ratchet Mechanism to Random Fluctuations Evolution of Hsp90's Mechanochemical Cycle
J.Mol.Biol. (2012), 423,3,462


S. Kienle, S. Liese, N. Schwierz, R.R. Netz, T.Hugel (2012)
The effect of temperature on single polypeptide adsorption
ChemPhysChem 2012, 982 - 989 Link:  [download]


C. Ratzke, F. Berkemeier and T. Hugel (2012)
Hsp90's mechano-chemical cycle is dominated by thermal fluctuations
PNAS, 109, 161–166 Link:  [download]


B.N. Balzer, T. Hugel (2012)
Surface & Interface Characterization: Single Molecule Detection & Manipulation
Polymer Science: A Comprehensive Reference; Elsevier: Amsterdam, 2012; pp 629-645 (2012)


D. Staple, M. Geisler, T. Hugel, L. Kreplak, H. Kreuzer (2011)
Forced desorption of polymers from interfaces
New Journal of Physcis, 13, 013025 Link:  [download]


Sonja Schmid, Thorsten Hugel (2011)
Regulatory Posttranslational Modifications in Hsp90 Can Be Compensated by Cochaperone Aha1
Molecular Cell, 41 (6), 619-620 Link:  [download]


M. Geisler, S. B. Xiao, E. M. Puchner, F. Gräter, T. Hugel (2010)
Controlling the Structure of Proteins at Surfaces
JACS, 132, 17277 - 17281 Link: [download]


C. Ratzke, M. Mickler, B. Hellenkamp, J. Buchner, T. Hugel (2010)
The dynamics of Hsp90 C-terminal dimerization is an important part of its conformational cycle
PNAS, 107, 16101 - 1630 Link: [download]


T. Hugel, C. Lumme (2010)
Bio-inspired novel design principles for artificial molecular motors
Curr. Opin. Biotechnol., 21, 683 - 689 Link:  [download}


I. Amin, M. Steenackers, N. Zhang, A. Beyer, X. Zhang, T. Pirzer, T. Hugel, R. Jordan, A. Gölzhäuser (2010)
Polymer Carpets
Small, 6, 1623 - 1630 Link:  [download]


M. Geisler, T. Hugel (2010)
Aging of Hydrogenated and Oxidized Diamond
Adv. Mater., 22, 398


M. Geisler, R. Netz, T. Hugel (2010)
Pulling a single molecule off a substrate reveals binding thermodynamics of cosolutes
Angew. Chem. Int. Ed., 49, 4730 - 4733


M. Geisler, B.N. Balzer, T. Hugel (2009)
Polymer Adhesion at the Solid–Liquid Interface Probed by a Single–Molecule Force Sensor
Small, 5, 24, 2864


M. Geisler, D. Horinek, T. Hugel (2009)
Single Molecule Adhesion Mechanics on Rough Surfaces
Macromolecules, 42, 23, 9338


T. Pirzer, T. Hugel (2009)
Adsorption Mechanism of Polypeptides and Their Location at Hydrophobic Interfaces
ChemPhysChem, 10, 16, 2795


T. Pirzer, T. Hugel (2009)
AFM spring constant determination in viscous liquids
Rev. Sci. Instrum., 80, 035110


T. Pirzer, M. Geisler, T. Scheibel, T. Hugel (2009)
Single molecule force measurements delineate salt, pH and surface effects on Biopolymer Adhesion
Phys.Biol., 6, 025004


M. Mickler, M. Hessling, C. Ratzke, J. Buchner, T. Hugel (2009)
The large conformational changes of Hsp90 are only weakly coupled to ATP-hydrolysis
Nat.Struct.Mol.Biol. 16, 281


M. Mickler, E. Schleiff, T. Hugel (2008)
From biological towards artificial molecular motors
ChemPhysChem, 9, 1503


D. Horinek, A. Serr, M. Geisler, T. Pirzer, U. Slotta,S. Q. Lud, J. A. Garrido, T. Scheibel, T. Hugel, R. R. Netz (2008)
Peptide adsorption on a hydrophobic surface results from an interplay of solvation, surface, and intrapeptide forces
PNAS, 105, 2842


M. Geisler, T. Pirzer, C. Ackerschott, S. Lud, J. Garrido, T. Scheibel, T. Hugel (2008)
Influence of Hofmeister Salts on the adhesion of spider silk proteins onto hydrophobic substrates: an AFM-based single molecule study
Langmuir, 24, 1350


M. Mickler, T. Hugel (2008)
Von molekularen Motoren zu künstlichen Nanomaschinen
Physik in unserer Zeit, 1, 14


T. Hugel, J. Michaelis, C. Hetherington, P. J. Jardine, S. Grimes, J. M. Walter, W. Falk, D. L. Anderson, C. Bustamante (2007)
Experimental Test of Connector Rotation during DNA Packaging into Bacteriophage phi29 Capsids
PLoS Biol 5(3): e59


G. Neuert, T. Hugel, R. R. Netz, H. E. Gaub (2006)
Elasticity of Poly(azobenzene-peptides)
Macromolecules 39, 789


R. Lugmaier, T. Hugel, M. Benoit, H. E. Gaub (2005)
Phase contrast and DIC illumination for AFM hybrids
Ultramicroscopy 104, 255


T. Hugel, M. Rief, H. E. Gaub, R. R. Netz (2005)
Enthalpic Elasticity of Highly Stretched Single Polymers: Quantitative Comparison of Ab-Initio Theory and AFM Experiments
Phys. Rev. Lett. 94, 048301


M.Seitz, C.Friedsam, W.Jöstl, T.Hugel. H.E.Gaub (2003)
Probing Surfaces with Single Polymers
ChemPhysChem 4, 986


N.B. Holland, T. Hugel, G. Neuert, D. Oesterhelt, L. Moroder, M. Seitz, H.E. Gaub (2003)
Single Molecule Force Spectroscopy of Azobenzene Polymers: Switching Elasticity of Single Photochromic Macromolecules
Macromolecules 36, 2015


D. W. Urry, T. Hugel, M. Seitz, H. E. Gaub, L. Sheiba, J. Dea, J. Xu, L. Hayes, F. Prochazka, and T. Parker (2003)
Elastomeric Proteins
Ed.: P. R. Shewry, A. S. Tatham, A. J. Bailey (2003) Ideal Protein Elasticity: Elastin Models, Cambridge University Press


T. Hugel, N. B. Holland, A. Cattani, L. Moroder, M. Seitz, H. E. Gaub (2002)
Single-Molecule Optomechanical Cycle
Science 296, 5570, 1103


M. Seitz, T. Hugel, H. E. Gaub (2002)
Ein lichtgetriebener Molekülmotor
Spektrum der Wissenschaft 10, 14


M.Seitz, T.Hugel, N.B.Holland, H.E.Gaub (2002)
Nanotechnology toward the Organic Photonics
H. Sasabe, GOOTech Ltd. Chitose, Single Molecule Force Spectroscopy by AFM-Related Techniques, Japan


D. W. Urry, T. Hugel, M. Seitz, H. E. Gaub, L. Sheiba, J. Dea, J. Xu and T. Parker (2002)
Phil. Trans. R. Soc. Lond. B 357, 1418: 169-184
Elastin: a Representative Ideal Protein Elastomer


T. Hugel, M. Seitz (2001)
The Study of Molecular Interactions by AFM Force Spectroscopy
Macromol. Rapid Commun. 22, 1


T. Hugel, M. Grosholz, H. Clausen-Schaumann, A. Pfau, H. Gaub, M. Seitz (2001)
Elasticity of Single Polyelectrolyte Chains and their desorption from solid supports studied by AFM based Single Molecule Force Spectroscopy
Macromolecules 34, 1039


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