Prof. Dr. Thorsten Hugel

Single molecule methods are essential for a thorough understanding of complex biological processes. They allow real time observation of molecular machines at work and their specific manipulation. Results of such experiments yield new insights into problems from fundamental physics at the nano-scale to the development of new drugs.

The multidisciplinarity of our research requires close collaborations with colleagues in biology, biochemistry, chemistry, medicine, biotechnology and physics. The results of the following projects are particularly relevant for:

  • Mechanism of Molecular Machines and their control (e.g. with drugs)
  • Understanding of signalling in biological systems
  • Protein folding and misfolding (e.g. hydrophobic effect, amyloid formation)
  • Biocompatibility of materials and coatings
  • Stimuli responsive biomaterials
  • Fundamental physics at the nano-scale at low Reynolds numbers

Latest Publications


S. Kienle, S. Liese, N. Schwierz, R.R. Netz, T.Hugel (2012)
The effect of temperature on single polypeptide adsorption
ChemPhysChem (2012) Link:  [download]


C. Ratzke, F. Berkemeier and T. Hugel (2012)
Hsp90's mechano-chemical cycle is dominated by thermal fluctuations
PNAS (2012), 109, 1, 161–166


B.N. Balzer, T. Hugel (2012)
Single-Molecule Detection and Manipulation
Comprehensive Polymer Science - 2nd edition (Elsevier), in press




Research Areas

Hsp90 Structure and Kinetics
Protein Import
Biomedical Physics
Adhesion Mechanics